PROJECT PNIII- P4-ID-PCE-2016-0765
 |
 |
Project financed by UEFISCDI Executive Agency for Higher Education, Research, Development and Innovation
Host institution: Politehnica University of Timişoara
Project type: Exploratory Research
Project code: PNIII- P4-ID-PCE-2016-0765
Project registration number: 169/01.08.2017
Project title: Advanced materials based on combustion-synthesized magnetic iron oxides nanoparticles and their cytotoxicity designed for cancer treatment
Acronym: MagNanoCytoTox
About the project
The increasingly higher incidence of the cancer cases in conjunction with the modest or rather unsatisfying results of the conventional treatments represent a solid argument for searching alternative solutions in controlling this disease.
Based on their remarkable properties, biomedical applications of iron oxides are by far the most interesting and take a special place in scientists’ concerns. Therefore, they are used in cancer treatment by magnetically-induced hyperthermia, drug delivery, magnetic separation and cellular selection, magnetic resonance imaging, etc.
The main original element of this funding application relies on the preparation of magnetic iron oxides nanoparticles via solution combustion synthesis and monitoring the influence of several working parameters: fuel type (EDTA, citric acid, glucose), oxidant/fuel molar ratio (fuel-rich compositions), ignition procedure (heating mantle, microwave field), working atmosphere (in air/no air), carbon and organic residues presence.
The as-prepared magnetic iron oxide nanoparticles will be coated with different surfactants (oleic acid, SiO2, PEG, Tween 80) and dispersed in PBS, in order to obtain stable colloidal suspensions. These will be used to assess the toxicological profile/biological activity of the iron oxide colloidal suspensions on normal/tumor liver and kidney cell lines.
The main goal of this project is to establish a correlation between synthesis conditions, properties of the naked/coated iron oxides nanoparticles and their selective cytotoxicity for cancer therapy. This would be the first time when such advanced materials are tested for cytotoxicity on normal/tumor liver and kidney cell lines. This opens an entirely new perspective on the potential use of combustion-synthesized iron oxide nanoparticles in cancer therapy by selective cytotoxicity.
Project team:
Project team: Păcurariu Cornelia – CV
Researcher: Ianoș Robert – CV
Researcher: Lazău Radu – CV
Researcher: Căprariu Aylin – CV
Researcher: Dehelean Cristina – CV
Researcher: Coricovac Dorina – CV
Researcher: Moacă Alina – CV
Researcher: Băbuță Roxana – CV
Researcher: Lăboșel Mihaela – CV
Project workplan - 2017, 2018, 2019
Results and dissemination - 2018, 2019
Contact:
Politehnica University Timisoara
Faculty of Industrial Chemistry and Environmental Engineering
P-ta Victoriei No.2, Timisoara 300006,
Tel. 0040-256-404144
Fax 0040-256-403060
